A Spicy John is when you drop an epic dump out of your third butthole. The third butthole only appears when one has been awoken through years of exclusively boofing psychedelics and watching The Fountain on repeat and absolute copious amounts of weed until entire enlightenment. The Spicy John is ridding your earthly vessel of any literal secular shit holding you down.

Briefly, "the realization that each random passerby is living a life as vivid and complex as your own." Originally from the Dictionary of Obscure Sorrows, which has a lot more beautiful neologism definitions like this you might enjoy.