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A syndrome had by people who don't get out the house much and have most of their conversations over the internet or text. People with this syndrome will start a conversation with someone, and proceed to get mad when they are not immediately replied to. They will constantly check to see if you reply and send you more messages if you do not.
John: Dude, Phil has a serious case of shut-in syndrome.
Sam: Why man?
John: Because. He texted me over 10 times in 2 minutes because I wouldn't reply to him.
Sam: He needs to get out the house more.
by Anon Y. Mous 74 April 09, 2012
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