To have made a massive, catastrophic blunder. An extension of the more common "screwed the pooch," which adds a more severe consequence to the metaphorical action.

A pick me is a woman that is willing to do anything for male approval. She will embarrass or throw other women under the bus to achieve this goal. The unfortunate thing about a pick me is usually the men they are trying to seek approval from are of poor quality and treat women badly, leaving little real benefit for the pick me.