a term usually used to describe someone that is: extremely annoying; acting in a prick-like manner; thinks they are much cooler than they really are; or is weasel or rat-like

A pick me is a woman that is willing to do anything for male approval. She will embarrass or throw other women under the bus to achieve this goal. The unfortunate thing about a pick me is usually the men they are trying to seek approval from are of poor quality and treat women badly, leaving little real benefit for the pick me.