1. The moment when a mind-altering substance begins to act in one's system.

2. The onset of the effect(s) of a mind-altering substance after its inhalation, ingestion or injection.
Dude, you'll definitely take-off before you finish smoking that giant blunt.
by m-fun December 15, 2019
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To make yourself throw up a little when you’ve been drinking. Prematurely to when one might “pull trig
That pregame hit different. I think I need to just take the top off.
by Thiccc nick October 09, 2020
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To throw up a little bit to make yourself feel better when you’ve been drinking.... prematurely to when one would “pull trig
Oh boy that pregame hit different. I need to take the top off!
by Thiccc nick October 09, 2020
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Take the waddle off
that poop you have when you're really desperate to go but only have a few seconds.

me: i really need to poop.
friend: we have to get our train in a minute.
me: i'll just go take the waddle off
by little man87 March 25, 2016
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Taking a piss off the Hollywood sign either is protesting the perfection wanted of people or physically urinating off said sign.
Man:”I went and got a drink.”
Man 2: “Oh no.”
Man: “Yeah I ended up Taking a piss off the Hollywood sign.”
Man 2: “Protesting?”
Man: “No... literally.”
by Actually It Is *insert thing* September 17, 2019
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Masturbating while on your period.

Combination of tampon + jack off.
I'm always so horny when I'm on my period, I tamp off so much.
by martianeyes December 08, 2014
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