The country girl lost her shoes ginger like; she will forever be your MSF
by Csanti September 26, 2017
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My Space Friend; People you add to your profile that you call friends.
by Jenn W. July 26, 2007
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Male Sexual Frusteration...the one week a month a guy get his chance to bitch never ending about shit

Take that women
Steve: Man that pisses me off!!!
Dan: What is wrong with you? it it MSF time?
by 2 Stale Crackers March 9, 2009
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Mean Sober Friend. Someone, in a group of people drinking and having fun, that is unhappy and angry.
When a man is talking to a group of women (can be generalized to other social interactions), sometimes one woman, usually the least attractive of the group, is not getting enough attention. While everyone else is laughing and having fun, she tries to interrupt by saying, "let's go somewhere else," or "I'm tired;" or verbally attacks the male suitor. She is an MSF.
by Jerry406 October 30, 2007
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An acronym for the game "Microsoft Flight Simulator 2020". Not to be confused for other editions.
Other editions have different acronyms, for example, "Microsoft Flight Simulator X" can be abbreviated as "fsx"
You really should consider buying msfs, it really is a good game.
by TigerStarlighter April 24, 2023
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An obscure transformation fetish webcomic on DeviantArt that has incredibly deep and in-depth lore for some unexplainable reason.
"MSF High is such a weird read. On one hand, it's clearly made by and for transformation fetishists to rock their socks off to, but on the other hand the lore is actually super well written and really in-depth."
by KrimsonKatt January 13, 2022
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