An insult or an explitive, addressing somebody who sleeps (ie. has sex with) one's mother. Often used to describe someone that you hate, but it's also used among close friends as a term of affection.

Still, in a way, a father, stepfather, or stepmother is a motherfucker; who else would be fucking one's mother?
Son: "'Sup, motherfucker?"

Father: "I'm your father! Don't talk to me like that!"

Son: "I meant literally. How else do you think I got here?"
by Lorelili March 13, 2006
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to curse someone out in a long rant when motherfucking is used repetitively.
So I called the nurse and she wouldnt even put me through to our doctor so i motherfucked her
by The Buddy Gecko Experience October 19, 2007
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used for comparison.
the second best, or second worst thing in all the universe
-it is colder than a motherfucker out here.
-it is hotter than a motherfucker in here
-this burger is tastier than a motherfucker
-god damn, that byatch is finer than a motherfucker.
by spanky July 24, 2003
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An commonly-used everyday word that usually means one of the following:

1) A person, usually male.
2) A place
3) A thing
4) An event
1) “He’s one cool ass motherfucker” / “I fuckin’ hate that motherfucker” / “Ehh.. that motherfucker’s alright. I’d rather chill with someone else though.”

2) “Let’s out this motherfucker.” / “We all up in this motherfucker” / “I say, we stop and smoke a bowl at the motherfucker over there.”

3) “Dude, just hand me the light and set the motherfucker down right here....” / “That’s the motherfucker I wanna buy.” / “Just hand me the fuckin’ motherfucker!”

4) “Dude, that motherfucker’s gonna KICK ASS tonight” / “Damn, this motherfucker is WACK. I say we out this motherfucker!” / “I’ll meet you at the motherfucker at seven, alright?”
by Mozzarella Enthusiast August 03, 2008
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A motherfucker can be known in the literal sense (by that I mean someone who has fucked your mother) but the true definition of a motherfucker is the following: a bad guy/ terrorist who means to bring evil into the world or just pisses Bruce Willis off.
"Yippee-ki-yay motherfucker" - Die Hard
"Yippee-ki-yay motherfucker" - Die Hard 2
"Yippee-ki-yay motherfucker" - Die Hard With A Vengeance
"Yippee-ki-yay motherfucker" - Die Hard 4.0/ Live Free or Die Hard
by Ewan JF December 24, 2009
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1) any person
2) any place
3) a word to emphasize the extent of something
"Hey motherfucker, turn the heat down! It's hot as a motherfucker in this motherfucker!"

"Yo motherfuckers, we need some food up in this motherfucker. I'm jonesing like a motherfucker for a cheeseburger."

"It's gettin' nutty in dis motherfucker, leave a nigga bloody in dis motherfucker. We in da cutty motherfucker. You done done too much, you got it comin' motherfucker." -Snoop Dogg
by Nick D March 18, 2003
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