League of Legends players' who are normal quiet players. All of a sudden, they say toxic remarks such as: "kill yourself" "i hope you jump off a bridge" "cancer" "autism" or all of the above at the same time. These are players who feel insecure about themselves. They're the type of players to act innocent if you call them out on their toxicity in post-game chat, If they act innocent after they flame someone mid-game then they have a severe case of League Syndrome. They're the type of players to justify their negative attitude.

If you want a master manipulator then you need someone who has League Syndrome because those fuckers take shit out of their ass and smear it on their chat box.
Player 1: "Can you stop being toxic?"
Player 2: "Shut the fuck up faggot piece of shit you cancerous toxic fuck, you're the toxic one."
Player 3: "Wow, HOLY LEAGUE SYNDROME"
by LeagueMaster3000 October 18, 2016
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The game is symbolized by a beautiful cancer that spreads like a butterfly. Your time on earth is numbered, but it's precious and it's worth it.
Ryan: Are you going to do your homework? You've been addicted to that game for 3 months
Bryan: No, there's no turning back. I'm on stage 4 League of Legends
by RVanonymous414 February 24, 2016
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The theory that everyone is part of a league of individuals whoose dating is restricted to the league. Leagues can be determined based on a number of factors, including physical appearance, profession, income, style of dress, preferred music genre, knowledge of game, etc.

According to league theory you are sure to be rejected by someone above your league, and u would be a loser to date someone below your league.
League theory. Dat sum old bullshit fer real dawg. You can date and fuck anyone you want! This goes for everyone.
by ZenWolf187 February 08, 2009
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A group advocating Southern independence.

Mission Statement

We seek to advance the cultural, social, economic, and political well-being and independence of the Southern people by all honourable means.

Joe finally had enough of the corrupt federal government so he went to www.dixienet.org & joined the League of the South
by Caleb Whorton February 04, 2009
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Basically crack cocaine. You will lose your friends. You will lose your girl-friend. You may lose your job.
Friends: "dude when's the last time you went outside"

You: "I've been playing Rocket League. What day is it?"
by Wietang-Clan April 02, 2016
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one of the best bands of the 1980s
featuring Phil Oakley, Susan Ann Sulley and Joanne Catherall.
formed in Sheffield.
The Human League are gonna be there!
by conor1939 July 20, 2009
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Stylish eSper Shooting Sports, with 3D sci-fi shooter with a third-person view and a techno beat. Play Death Match or Touch Down (capture the flag) modes and earn money to buy armor or more weapons. A very addictive game, and its something to definetly look at.
Timmy: Hey guys, lets play "S4 League"!
Ralph: F-ck yeah man, its awsome; it makes Runescape look like french bread.
Blake: HEY GUYS DONT MAKE FUN OF RUNESCAPE, ITS COOL!
Timmy: Dude.. *shakes head*
by SKpro December 27, 2008
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