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When two people go in for a handshake and one person puts up knuckles and the other person goes for a standard handshake. A fucked up handshake or a fucked up attempt at one.
The boss went to shake my hand and I gave him knuckles on accident. What a knucklefuckle.
by DV8DUG September 27, 2017
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2
ramming a whole fist up one's anus, while jizzing on his/her genitals.
i totaly knucklefuckled that tramp last night in the hotel room.
by shaggy2dope69muthafacko January 20, 2009
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