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verb.: An action typically seen performed by enraged apes who run with their fists closed when moving to attack someone: hence "knuckle" running. Buldging eyes and bared teeth are also commonly part of this reaction.

Also used to describe a human in a state of rage that is comparable to an angry ape.
"You're in for a bad day: John came knuckle-running into the office twenty minutes ago bellowing something about you forgetting half of the prices you were supposed to add to that quote you were working on."

or

Him: "So, how would your mom react if I stayed the night?"
Her: "She'd be fine. Dad would knuckle-run you right off of the property, though."
Him: "Ah. I'll go home."
Her: "Good plan."
by Anne Hughes July 04, 2011
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Aug 11 Word of the Day
A phrase to describe someone who is cognitively degenerating. Synonym of "going off the deep end". Can have varying degrees of severity.

Reference to the song "Hey You" by Pink Floyd. The line "and the worms ate into his brain" makes no sense in an otherwise linear and literal narration throughout the lyrics.
"My boyfriend has a total case of brain worms. He told me the cat was bugged so the Feds could listen in on us having sex..."

or

"You totally stumbled over that entire sentence. Can't speak English all of a sudden? What, do you have brain worms?"
by _Jez_ October 03, 2009
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