1. In Baseball or Softball, to achieve a home run by hitting the ball so hard that not even the player who stayed home with his sick kids could catch it.

2. A single hit that is so vicious that its effects are felt for a while afterwards, usually through flying backwards, falling to the ground, writhing in pain, and throwing up. Bonus points if you do it with a baseball bat.
Aaron tried to sneak up on me while I was blindfolded, but I kicked him in the groin, which caused him to be knocked out of the park.
by El Singario February 11, 2006
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- Good luck with your game!
- Thanks! I`ll knock it out of the park!
by Fjall October 15, 2015
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A person who succeeds at everything they do.
Me: I love Paul Allen! That guy right there is a real knock-it-out-of-the-park-er!
You: Yeah, I hate him.
by MalumLibrum958 January 10, 2023
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