a whore that is usually ugly and either fat or anorexic; so dirty that you might actually contract an std by walking past her; her std's "jump" off her body onto yours as you walk past

A pick me is a woman that is willing to do anything for male approval. She will embarrass or throw other women under the bus to achieve this goal. The unfortunate thing about a pick me is usually the men they are trying to seek approval from are of poor quality and treat women badly, leaving little real benefit for the pick me.