1. An actor who portrayed Uncle Jesse on Full House from 1987-1995, he originally became famous from starring in a soap opera called general hospital, and was on a show recently called ER, and has also done some Broadway shows in the early 2000's.

2. The sexiest man alive, great personality and a sultry voice.
"Oh my god who is that hot guy on full house?"
"Oh that's uncle Jesse aka John stamos aka the sexiest man alive"
by Madison P April 29, 2015
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it is quite possible that john stamos is the coolest individual to walk the earth. he has it all, from sweet hair to good looks to tight pants. definitely the best character from full house, aka uncle jesse. the "epitomy of coolness", john stamos is the guy every girl wants to date. every guy wants him as their best friend. he knows whats hip, cool, and he teaches DJ, stephanie, and michelle every moral they've ever learned.
john stamos` ex-wifes name is rebecca. my name is rebecca. coincidence? i think not. marry me, john stamos.

john stamos is the hottest guy ever, next to brad pitt.

jeez, look at that guy`s hair. he looks exactly like john stamos. sweet.
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1. Uncle Jessie from Full House
2. Taking a poop, while masterbating, and eating a bowl of cereal. A variation of the Bob Saget.
I did a John Stamos after watching full house.
by L. Roman July 16, 2006
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A Vodka shot lit on fire for a good 3 seconds before dumping it in YooHoo (chocolate milk) and chugging it.
Margaritas are sour, and John Stamos are sweet.
by muffinmonk May 5, 2011
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He is the hottest American actor in the world. He slayed In she show full house as his character “uncle Jesse” he is fucking incredible and anyone who says he isn’t doesn’t have a fucking brain
John Stamos is fucking hot
by Fullhousesuperfan January 23, 2019
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A beverage that consists of Mountain Dew and Lemonade.
Person 1 : "Hey man what are you drinking?"
Person 2: "I'm just having a John stamos"
by Tang tickler cockblast July 25, 2017
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Male actor who once portrayed Uncle Jesse in full house. Got his start by starring in such Gay Porn films as CliffBanger and Back Door Gardeners III. Was also caught in connection with Rob Lowe's seduction of two under aged males.
"*Farts*....Mhmmmm....."
"Unlce Jesse?"
"(Breathes deep and reaches pervertedly for the little Olsen girl)"
"(Olsen girl screams)"
"YOU'RE GAY JOHN STAMOS!"
by AssMan99 August 19, 2006
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