Jamie obrien is a slur you can call someone if they are either... a simp, watches 'how to become alpha male' videos, treats women like gods, theyre self worth is extremley low, threathens to rape women, threatens to kill himself or tells people to kill themselves.
"Woah did that guy just say he would suck lily murphys vagina??"
"Damn that guys is a total JAMIE O'BRIEN"
"Damn that guys is a total JAMIE O'BRIEN"
by Egg1273 June 17, 2022
Jamie O'Brien is a virus that you can catch, in the form of a person, its basically a cause of madatroy homo-sexuality.
Jim : Hey dude you don't look so good.
Harlod : Yeah, I turned gay last night, I have Jamie O'Brien.
Harlod : Yeah, I turned gay last night, I have Jamie O'Brien.
by Danielle199 January 31, 2009