HSIOW is a resturant created by George Carlin. HSIOW is an acronym for "Holy Shit Its Only Wednesday"
George Carlin says, "There would be alot more drinking if it were always Wednesday"

The safeguarding of Earth and other worlds from biological cross-contamination (i.e. billionaires with too much time on their hands).

Also known as “planetary protection.” Planetary protection / quarantine “reflects both the unknown nature of the space environment and the desire of the scientific community to preserve the pristine nature of celestial bodies until they can be studied in detail.”

There are two types of interplanetary contamination. Forward contamination is the transfer of viable organisms from Earth to another celestial body. Back contamination is the transfer of extraterrestrial organisms, if such exist, back to the Earth's biosphere.

An acronym standing for "Holy shit it's only Wednesday." This was a term originally coined by George Carlin as a reason to drink.

George Carlin, "You Are All Diseased", the part of the show where he is talking about 'names' which is about 40 minutes into the routine.

He does not care for TGI Friday's and feels they should all be bombed. He'd call a bar "HSIOW" and believes that people would drink a lot more liquor if they thought it was only Wednesday.

Holy Shit It's Only Wednesday
you'll drink more thinking it's Wednesday all the time