noun. "Hot tranny mess" was coined in 2008 by Christian Siriano, an American fashion designer and the winner of the fourth season of American reality show Project Runway. His remark incensed the transgendered community. He soon apologized for the remark.

The term is now used to describe generically anyone (regardless of sexual identity) who is any of these: a fashion nightmare, a bad dancer, sloppy drunk, has atrocious manners, tells hilarious off-color jokes, is very funny, is flamboyant, or whose life is in shambles or an endless comedy of errors.

The safeguarding of Earth and other worlds from biological cross-contamination (i.e. billionaires with too much time on their hands).

Also known as “planetary protection.” Planetary protection / quarantine “reflects both the unknown nature of the space environment and the desire of the scientific community to preserve the pristine nature of celestial bodies until they can be studied in detail.”

There are two types of interplanetary contamination. Forward contamination is the transfer of viable organisms from Earth to another celestial body. Back contamination is the transfer of extraterrestrial organisms, if such exist, back to the Earth's biosphere.

a more colorful way of calling someone a 'hot mess', itself a way of calling someone a mess. The added color of 'tranny' and 'hot' takes the edge off of calling someone directly a 'mess'. It can have a range of connotation, from negative to neutral. Sometimes, ironically, it can be a compliment.
Alone, tranny is used as a greeting among gay men.