When you hookup with a guy or girl and they want nothing to do with you the next day. Symptoms can range from being completely ignorant to last night's events to nausea and possible vomiting due to a state of frustration where you don't know what to do with yourself or the hookup partner
Lauren: Oh my god, I hooked up with this guy last night and he won't talk to me anymore. I just realized that he's the biggest jerk and I feel like shit now.
Sarah: Wow that sounds bad. You're probably suffering from hookup syndrome.
Sarah: Wow that sounds bad. You're probably suffering from hookup syndrome.
by winterbabe300 December 24, 2010