Smoking a joint with more than one strain of marijuana.
"Yo Glynis, you wanna hit a combo and go to space?"
by My Point Exactly October 6, 2011
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1. A person who is so ugly they might as well have just experienced being hit 5 times in a row, like in Street Fighter.

2. A different way to say shit. When 5 hit combo is displayed in a game, it looks like it says the word shit.
1. (Seeing a really ugly girl:) "5 Hit Combo, man."

2. "She said don't come near her again, man."
"Oh, 5 Hit Combo."
by Dan In The World April 5, 2006
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Slapping A woman Across The Face With Your Penis First Then
Shortly Followed By The Left And Right Testicles Seperately. Usually used after doing something inapropriate.
Last night I gave this hoe a Robert Plant Three Hit Combo after she sucked my cock poorly.
by Chuck G January 10, 2008
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