The act of driving a car on a highway as fast as it can go. Sometimes multiple cars will compete in a highway run to see which vehicle has the highest top speed.
Yo, we gonna do a highway run tonight.
by Mad_Matt March 01, 2014
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When you’re on a road trip and you experience diarrhea because of all the gas station food you eat.
Kevin got the highway runs on our road trip to Arizona.
by Papa Kryn June 28, 2021
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