The act of, when out with friends and having a particularly engaging conversation, coming out with a completely inane or otherwise offensive/distasteful/unfunny comment that is so heinous it kills the conversation dead.
Friend 1: "Aww man that's so funny..."
Friend 2: "Yeah, tonight's been really cool."
You: "Hey, aren't spastics funny!?"
All: <silence>
by Barlos the Jackal November 25, 2003
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Your having sex and you really need to shit, but you dont wanna stop banging her, so u shit in ur hand and slap her in the face.
While haveing sex, Paul really needed to shit so he whiped out the shity hand grenade on the bitch.
by gilli-spree March 08, 2007
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when your fisting someone, whether anal or vaginal, and open your hand like an explosion while your hand is inside them.
chick#1 "Jim gave me a Mexican Hand grenade last night."

chick#2 "really, and how was that?"

chick#1 "interestingly fun."
by Mexican with Hand grenades November 27, 2009
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When someone takes fecal matter (fresh or dry) and procedes to use it as a weapon, such as a snowball.
Dude I was walking home from the bus just yesterday when this douchebag hit me in the face with a Harlem Hand Grenade
by B-Man5455 January 31, 2009
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Where someone throws a used condom at their partner and a yells "Fire in the hole."
"Dude i cant believe you actually did, the frosty hand grenade."

"I know i hit her right in the face. She had no idea."

by Anthony and Matty January 04, 2009
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(n) The Samsung Note 7, which gained infamy for its exploding battery. The phone was also featured as a grenade in GTA 5 via a mod.
My God... Is that guy using a Hipster Hand Grenade!?! Run!
by Funmunke March 31, 2017
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