The situation you are in if your dropship crashes and leaves you stranded on a planet full of nasty extra terrestrials.

A pick me is a woman that is willing to do anything for male approval. She will embarrass or throw other women under the bus to achieve this goal. The unfortunate thing about a pick me is usually the men they are trying to seek approval from are of poor quality and treat women badly, leaving little real benefit for the pick me.

A sure sign that the game just kicked your ass...

when you get married

The alternative to You Are Dead! in games that are not Resident Evil

a situation has ended unsuccessfully

1) Saying that you have the situation in the palm of your hand.
2) When something happens that causes you to give up.