An expression of total discussed in someone as to why they cannot do something, and you feel as if they can at least do it for the sake of a piece of shit if nothing else at all matters.
Dad: Son, please take out the trash for your mother.
Son: But why? It is not like I have to do what you say and you can’t make me!
Dad: Well for shit sakes, you could at least do something around the house every now and then!
by Billy BullSchitter August 05, 2016
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when a situation calls for a response where a more pronounced explative does not quite apply. or when a situation is noticed where simply saying shit is not enough and requires special recognition.
shelly: dan quit saying fuck so much!
dan: why the fuck not shelly?
shelly: OH FOR SHIT'S SAKE.

jamie: help, i can't seem to find my vibrator.
dan: i think shelly must have broken it or ran down the batteries again.
shelly: OH FOR SHIT'S SAKE!
by slapnuts208 August 09, 2009
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totally overwhelmed by nonsensical random events or situations.
For shit sakes, I need to replace the clutch because my paid warranty refuses to cover parts and labor.
by SteakAlwaysMadeMeEatMyLimaBean December 19, 2015
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