A cardinal point of the compass, 045 degrees.
Look in the mirror, your right eye is ENE of your nostrils.
by harry flashman August 12, 2003
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En is a one syllable response to a situation which causes trolley. The longer and more drawn out the pronunciation symbolises the sheer magnitude of trolley experienced. When typed the number of n's typed also adds emphasis.
"Dude, after she dumped you and kept the ring she called me and asked if she could stay the night"
Response
"Ennnnnnnnnnn!!!"

"Dude how was that movie with Leonardo DiCaprio in it?"
Response
"En!"
by Mordy November 28, 2004
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A Mexican-Samoan super human inbred
ene is the coolest
by tom ato August 11, 2003
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The typical texting expression someone has when the just don't care about anything. A poker face of sorts.
Kyle: How are you today? UwU
Ryan: Eh. ene
by BabiDaAlien December 19, 2018
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A hip abbreviation for evolution by natural selection that evolutionary biologists use in a hopeless attempt to sound cool.
Bio Student: Yo, dawg. Thinking of writing my dissertation on ENS.
Other Student: Shut the hell up.
by The Real Richard Dawkins February 24, 2015
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