Top definition
a website mostly made out of NSFW furry artwork, there are some SFW but everyone ignores them

It is also home to a lot of cursed artworks
Person 1: yo, check out this WoW porn I found!
Person 2: Hell Nah, I'd rather jack off to the shit on e621 than see that shit
by ThunderTheFurry October 25, 2020
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May 18 Word of the Day
When you think up something brilliantly righteous while baked.
X: I had this great highdea last night
Y: You clearly were philosopher stoned.
by TripleWest September 03, 2012
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2
a place where can find a lot of furry porn and be able to sort by many different categories like if you were looking at rule 34
me: alright guys im going to jack off to furry porn on e621

my friend: wait what the fuck
by zeno the protogen November 28, 2020
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3
It's the E number for Monosodium Glutamate (aka MSG).

The furry imageboard with the same name most likely named itself E621 to address how 'tasty' their content is.

Funnily enough, there's a forum named E926 (the E number for bleach) that exists as an eye-bleach after one views the 'tasty' content of E621.
Person 1: E621 is love, E621 is life

Person 2: Ew, miss me with that furry shit
by Obv troll is obvious March 23, 2021
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4
E-number for Monosodium Glutamate, a common food additive that has a distinct umami taste.

Also refers to a particular website...
Alice: E621 tastes really good!
John: What's E621?
Alice: You'll soon find out...
by レム July 23, 2020
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5
e621 is an image board focused on furry artwork as well as other fetish art.. Do you know what furries are? You should.

Much of the content is pornographic in nature, and it contains many hardcore fetishes. Its cleaner counterpart is e926.
"e621 is a cursed website."
by Deutsches Kaiserreich March 02, 2020
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6
One of the Seven Circles of internet Hell, where furries and other stains on humanity flock. Some call it the off-brand rule34, while for others this is their most-visited site. Usually used as a gallery for both NSFW and SFW art. Porn posted here typically is composed of ponies, anthromorphic animals with human features, cartoons and various video game characters, ranging from Ankha from Animal Crossing to Ren & Stimpy. Some more well-known characters are : Various Pokemon, MLP characters and even Deathclaws from the Fallout series. Art is organized by tags that tell one or more things in the image. e621 is also home to porn that takes things to the extreme.
Person 1 : Dude, have you seen how sexy this gardevoir is? I found it on e621
Person 2: You know I'm into horses, right? And rule34 is the better site .
by PanisInTheAnus October 26, 2017
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