The situation one finds himself in when the stock of controlled substances runs out.

If not remedied, the situation may lead to intense irritation, boredom, or withdrawal symptoms.

when you're hungover as shit after a spending a night drunk as a skunk

a drug problem is when an unsuspecting person has been drugged by someone as a result of organized crime or some other form of malicious mischief. a drug problem is best usually ongoing and administered in a variety of ways through coffee, cups, clothing, projectiles, food or other sneaky means like toothpaste, contact lenses etc.