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Shortened form of 'downtown.'

In NYC drug slang, 'downtown' is heroin.

To help speed-up business transactions, saying what you want, as quickly as possible, helps all involved.
Conversation with dealer:

Dealer: 'what do you need?'
Customer: 'just gimme two down, for now.'
by UNOwenNYC May 07, 2012
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17
Def1 Slang term as in "with it" Or "Cool"

Def2: A song by blink 182

Def3: An awesome southern metal band from new orleans.

Def4: Downward direction.
Kid1: Hey you wanna go to my house after school?

Kid2: Sure Im down with that.
by Slayerkid16 May 30, 2009
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18
The ultra soft, ultra warm, non flight feathers found in ducks, geese, and other fowl, used in pillows, comforters, jackets, and other items where warmth and lightness are important. Down is measured in fill power.
Mmm, that's a warm down comforter. I bet you could sleep naked with that!
by michael November 11, 2003
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19
Urban slang signifying total agreement with and/or understanding of a person or concept.
I'm down with G-O-D.
Roscoe is ma' boy; I'm down with that brother.
by Storm June 07, 2003
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