1) person having multiple diseases, i.e. aids, herpes, genital warts, etc. etc. all rolled into one
2) person having one or more uncurable diseases
3) what a professional prostitute is in her later years

Referring to women who are sexually or romantically attracted to other women. Applies to both lesbians and bisexual women, as it is only the same-sex attraction that matters, not any other attractions the women may have.

Originates from the Greek poet Sappho, a bisexual woman from the Isle of Lesbos, from which we get the term lesbian.