Refers to an extreme thirst brought about while high on marijuana.

Symptoms include: Extremely dry mouth, Excessive thirst, and a motivation to drink everything in sight.

Also referred to as simply, deep south
James Bonfire had Deep South Cotton Mouth last night and drank 5 water bottles in an hour
by James Bonfire June 24, 2011
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When a stoner won't stop complaining about having cotton mouth after smoking.
"Man shut the fuck up about your cotton mouth"

"But it's like someone shoved cotton balls in my mouth"

"Don't be such a Cotton mouthed Carl"
by Spootybeaver113 May 24, 2012
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Cotton Mouth Killer, or CMK, is an energy drink from Norway. It has blueberry and guava flavour, and is specifically designed to kill your cotton mouth. When your thirst is dire - an ice cold can of Cotton Mouth Killer extinguishes it like an ocean hitting a fire.
Thirsty guy: "Dude. My mouth is so dry. I would pay such large amounts of money for a delicious bevarage right now."
Friend: "Have a CMK, bro. Cotton Mouth Killer will quench your thirst."
by Javisst June 2, 2017
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