Noun:

A mental affliction characterized by a self-centered and condescending state of mind produced upon moving to a major city from another town. Those with city syndrome think their city and its inhabitants are better than other places and their populations Thus, they rarely travel and look down on other areas/people.

Particularly present in NYC, this disease is highly resistant to treatment because sufferers rarely acknowledge their pathology.
Friend: (just moved to nyc from nj): I just can't go back to the suburbs anymore. I just can't do it, its way too boring.

Me: Fuck you, you arrogant bastard! You got City Syndrome! Since you moved to NYC from Jersey you think you're better than everyone else. You're not you pompous asshole!
by Limit531 November 26, 2009
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When individuals (or groups) originally from the capital cities of the world (or metropolitan) assume an air of superiority over everyone else. Cities where the problem is prevalent include; London, Edinburgh, Belfast, Dublin, Paris, Athens, Rome, Berlin, Vilnius, Vienna, Barcelona, Lisbon, Oslo, Stockholm, Helsinki, Washington, D.C., Mexico City, Ottawa, Cape Town, New Delhi, Beijing and Tokyo.

The phenomenon (disease) is mainly confined to Europe, North America and the developed english speaking world. However we cannot rule out its existence elsewhere.
Bar and club social scenario in Edinburgh

Man 1: "Hey bro, have you noticed how Sebastian from London and his bitches are staring at us?"
Man 2: "Yes indeed, it seemed to happen more once we told them we were from Leicester."

Man 1: "Yeah that condescending look, down the nose and all that. As if he's above."
Man 2: "Bro I know, but don't worry that mandem has capital city syndrome - its like just because theres a political office

in his city and its richer with more of a cultural hub. He somehow thinks it defines his superior nature."

Man 1: "Narcissistic Wankers"
Man 2: "Indeed, yeah apparently even Edinburgh folks and Dublin folks are also afflicted with the disease! Its like

everyone else in the counties doesn't matter!"
by The_Resurrected October 10, 2018
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When a smaller city talks down on a larger city due to insecurity of its own size and/or having less culture, music, art, employment. Usually this happens between two cities that are relatively close to one another.

Some great West Coast examples are Portland and Seattle, Los Angeles and San Francisco.

Ironically, the smaller city will always talk shit on the larger city, but the larger city will speak glowingly of the smaller one, often referring it to as "charming" or "cute". Often, larger city residents will visit the smaller city on weekend trips and mini-breaks while the smaller city will often have to come out of necessity- i.e. jobs or to see their favorite band play.
San Franciscan: God! I hate those superficial brainless L.A. types! The sun must absorb most of their brain cells because you can't have a single decent conversation down there! Oh, by the way, I have a few job interviews down there because I'm sick of living on unemployment in SF...No I don't have second city syndrome, that place just sucks

Angeleno: Oh my god! I totally went to Frisco and it was like awesome! It's so foggy and cute! And theres all these hills! Oh my god let's go again next weekend and have brunch! At that one place with those guys with all the tattoos! Soooo much fun!

Portlander: Seattle totally sucks! Its full of these corporate liberal hypocrites that are rude and fake...man. Whatever- no, I don't have 2nd city Syndrome. I keep it real in the streets...P-town for life, blood. (stupid handshake/and or tattoo revealing a "portland" icon)...Hey... we need to get tix to see Skrillex play next weekend...yeah, he's only playing in Seattle...

Seattelite: So Jenny and I went down to Portland the other weekend and had brunch at that great new place! What a nice city...we stayed at the co-op bed & breakfast too with the organic rose bushes...beautiful! Let's go down there again soon.
by W.Coastie Girl July 8, 2012
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"Sex and The City" syndrome refers to a woman who needs a man to validate her existence. This goes for both serial daters, and women who consider themselves (or are) serial monogamists for the same reason.

It is a very sad, and might I say, quite pathetic, syndrome.

White women seem to be the primary sufferers, however, women from any race or ethnic background can suffer from Sex and The City syndrome.

This term is primarily used to define a certain attitude the show gave off. The attitude that despite being a successful, beautiful woman..one has to have a man to feel completely fulfilled.
1. A woman who continuously dates different men because she is afraid to be alone, or because she feels (consciously or subconsciously) that having a man validates her existence. This can apply to women who are constantly looking to get a relationship out of these dates, or women who are constantly looking for sex as a means to fulfill some long empty void.

"My best friend is going on ANOTHER date...she was so depressed last week because "no one wanted her." Ugh, she definitely has Sex and The City Syndrome!"

2. A woman who has been in a monogamous relationship for a while with a man who treats her badly or unequally, yet she stays with him for fear of being alone, or fear that without him her existence will no longer be worthwhile.

"She is crying again over something her boyfriend did to her...he treats her like such crap, yet stays with him. Its like she needs him to validate her existence, or she is so afraid and unsure of herself she feels she needs a man...a man who treats her like crap! She SO has Sex and The City Syndrome..its sad."
by helloimlulu September 10, 2011
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Being a female in favor of circumcision or thinking intact penises are dirty. Obviously hypocritical, since vulvas and vaginas smell a lot stronger.
From the show: I am so circumcising my son. I don't want anyone calling him a shar pei.
Girl 1: My four-year-old host brother from Spain was circumcised.
Girl 2: Why wait so long?
Someone who actually knows what the fuck he or she is talking about: Why do it at all?
Anyone who has Sex and the City Syndrome is someone I won't waste my time with.
by Phish Taco March 10, 2008
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n. An unfortunate condition in which the victim becomes involved with the most attractive, available male/female in a small community just because they are the most attractive, available male/female in said community.
"I sure am glad I moved away before I caught the Sioux City Syndrome!"

"Look at poor Sally, she caught the Sioux City Syndrome and got knocked up by that mildly attractive meth dealer."
by tracydinosaurs March 3, 2014
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The tendency of a New York City resident to only judge other cities by how they compare to New York. By living in the largest grid city in their country, other cities, in comparison, seem small, spread out, slow-paced, too quiet, poorly planned, or just not like cities at all.
Friend: "So how do you like Boston so far?"
NYC Resident: "It's a quaint town, but I'm not a fan, it's just an older, smaller, less-populated NYC."
Friend: "Dude you've been living in Manhattan for five months, you can't have New York City Syndrome already."

Friend: "Look at this instagram video of Shinjuku, Tokyo, the streets look so calm and narrow with little shops and ramen places scattered around. I wanna visit so badly."
NYC Resident: "Aww yeah! It's like a tiny little New York. A cute mini city!"
Friend: "Bro Toyko is the largest city in the world, can you quit it with the condescending NYC Syndrome?"
by Mametchi January 8, 2023
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