When someone is rejected by a love interest of the same gender because they're heterosexual.
"Man, I was totally chromozoned last night, turns out Ashley's only into dudes."
by toreadorean January 04, 2014
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When your homie keeps asking you to play fortnite and you can clearly tell he got no sleep last night because he was playing fortnite all night. Basicaly some who is just too adicted to fortnite and now always imagines hes playing fortnite in real life
John: Hey Frank you wanna play some fort tonight?

Frank: I gotta do homework tonight besides ive played with you every other day this week

John: WATCH OUT THERE SHOOTING AT US!

Frank: OH SHIT IS IT THE SCHOOL SHOOTERS?!

John: No its just those two gay kids who tried to take me on with their scars but im too good at fortnite for them

Frank: Oh of course, i forgot you have Fortnite Chromozonal Disorder
by TheGayestKidOutThere February 25, 2018
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When a retard tries to roast you but can’t spell.
retard - “How many chromozones do you have”
Person - “What?”
by John the Choo Choo car April 06, 2021
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When someone with Down Syndrome is put in the "'Friendzone" by someone else with Down Syndrome
That downy just chromozoned me! wtf!
by DownToTheLeft March 08, 2017
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