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Noun: A mysterious and presumably potent drug named for its close association with American actor Charlie Sheen, its most famous user. Over-consumption may lead to wild, drug-fueled benders, failed marriages, and an alarming amount of time spent in the company of prostitutes and other questionable personalities.

Inexplicably, Charlie Sheen (the drug) does not show up on drug tests.

May also refer to a large joint packed with a wide assortment of drugs, including but not limited to: marijuana, opium, Ecstasy, heroin, cocaine, amphetamines, etc. A close relative to the Jeffrey.
"Yeah, I am on a drug - it's called Charlie Sheen." - Charlie Sheen

"I have one speed. I have one gear. Go!" - Charlie Sheen, under the influence of Charlie Sheen
by mind-fuck February 28, 2011
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It's a drug. Only Winners take.
Kate: I heard that Tommy died this weekend. What happened?

Bob: I heard he tried some Drug called "Charlie Sheen" I guess his face melted off and his children were crying because his body exploded tiger blood all over the walls!!

Kate: Wow!! Crazy stuff.
by warlock11 March 04, 2011
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Charlie Sheen is a drug that is unavailable because if you try it once, your face will melt off and your children will weep over your exploded body.
Dude, where is your face?!?!? Someone spiked my drink with Charlie Sheen last weekend.
by pd293 March 10, 2011
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Actor Charlie Sheen's drug of choice. Consists of cocaine, tiger's blood, and vodka.
Man, I got totally wasted off of some awesome Charlie Sheen last night.
by Flipflops76 March 09, 2011
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A warlock/rock star from Mars. Usually extremely tired of pretending he's not special.Great at making money off of his own nervous breakdown. Highly superior to the rest of the human race. His only flaw is that in case of a transfusion, he needs to transfuse his own blood with that of a tigers.
What's the difference between Charlie Sheen and an ordinary human? Charlie Sheen isn't a troll.
by juicalicious March 22, 2011
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A drug that is highly addictive that offers a high lasting a lifetime.

Side effects include:

winning
tigers blood
melting of face
Charlie sheen: I'm on a drug. It's called Charlie sheen. If you tried it your face would probably melt off.

Reporter: ...

Charlie sheen: WINNING!
by Savvy6oh7 March 20, 2011
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