The chemical in chili peppers that makes them "hot." Actually a mild irritant.
"How many times more capsaicin does a habañero have than a jalapeño?"
by Qit January 21, 2004
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The inability to handle spice from peppers. The other term for someone who is capsaicin intolerant is "a pussy."
Charlie: Well, I was born without the genetics to handle capsaicin which is the active component in hot sauces and peppers, so when I get capsaicin my body just shuts down and goes into overdrive, it's a disaster.

codemiko: Wait you actually... is it like an allergic reaction?

Charlie: Yeah, it's a medical condition, it's out of my control is what it is.

codemiko: Are you just a pussy?

Charlie: No, no no no, I believe the correct terminology is capsaicin intolerant.

codemiko: So a pussy.
by Ian A. Box December 23, 2020
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A pussy who can’t handle the slightest bit of spice
You know Charlie over there is a Capsaicin Intolerant as he can’t handle the slightest bit of spice
by jamlessdoughnut December 23, 2020
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jim - "yo did you hear that critikal is Capsaicin Intolerant?"
dave - "nah he just a pussy"
by crazy gravy December 23, 2020
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