1) Origination: to do something with six of an object
2) Current: with extreme enthusiasm or extreme effort
Some girl: I felt so sick after eating Dentyne Ice by the sixes.
Some guy: Yeah, it didn't go very well with that beef jerky.
Other guy: Really? I thought it was great! We should totally do it again...
(All in unison): BY THE SIXES!!
by Edward I May 02, 2006
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Signal strength meter on radio, indicating strongest signal. Therefore, to comprehend completely.
I read you six by six.
by oldchief June 16, 2004
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A hamburger from In-N-Out with 6 patties and 6 slices of cheese. Very tasty, very big.
"I want a 6 x 6, animal style, with grilled onions"

"Would you like fries with that?"
by el jefe June 11, 2004
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An In n' Out burger with 6 pieces of meat and 6 pieces of cheese.
I could have bought a double double or a three by three, but I instead opted for the six by six because I'm hungry and hardcore
by ayeleleyee June 15, 2004
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A huge burger from In-n-Out (a western US chain) comprised of 6 patties of meat and 6 slices of cheese. See "double double" and "four by four".
"Welcome to In-n-Out, may I take your order?"
"I'll have a six by six and a vanilla shake."
"That'll be $7.50, fattie"
by duncan June 08, 2004
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six rows of six ppl
Then ants go marching six by six HoorAh! HooRah!
by C-Rad June 15, 2004
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an average length penis that is thicker than average (6 inches long and 6 inches in circumference)
On an Internet chat for men only:
Person A: Are you hung?
Person B: No more than average but thick... I'm a 6x6.
by PlaceHolder June 16, 2004
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