Fed up, pissed off, disappointed.
Thought by some to have come from a euphemism for 'buggered', it is actually of 14th Century English origin, the original phrase was to be in a "Brown study", where 'brown' = dark & sombre, 'study' = a daydreamy state. Meaning has shifted to today's meaning, and the phrase has become "Browned off".

1. to be very annoyed
2. another word for thorough cooking of meat
3. to be off your face on heroin

V. To wear ones patience thin, to be vexatious to the spirit

Originated by Lil Wayne in the song "Miss Me" By Drake. Meaning for one individual to perform oral sex on a male who has just had anal sex with them. Not limited to just this definition but this is clearly the meaning at which the artist was referring to.

a football fan's way of saying "i have to take a dump."

(v.) to poo