When no matter how much you try you are always a loser.

The Nussy, or the “nose pussy”, if you will, was discovered during the corona virus pandemic of 2020. People that had to be tested for Covid-19 had to have their nose swabbed right where the brain connects, which often led to people rolling back their eyes and gagging.

A nose-swab-fetish developed from this, because we, as humans, ruin everything.

This is two different things:
A comic strip that comes in a lot of Sunday newspapers.
And a term for somebody who's pathetic, just can't win, or never seems to do anything right.