To have taken a very large dump; as if one had actually lifted off the toilet seat while taking a massive shit.
"I really had to poop. Blasted off big time..."
by yes juanito yes August 08, 2014
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Taking a hit of DMT (Dimethyltryptamine), as this will be your rocket ship to the moon!
It's been a long night, time to blast off and watch the sunrise.
by pocketfrog April 15, 2011
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to just not think and space out for a hot sec
Kate didn’t respond when i called her name, I bet she’s blasting off again.
by funtimesarefun March 12, 2019
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The act of smoking marijuana while you are tripping on acid.
(guy) Yo you want to smoke a blunt?

(guy2) Nah man im trippin balls

(guy1) I know but i wanna blast off!
by Lucidreamer February 16, 2011
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I had a hard blast off in her face after that mic check!
by Duke February 24, 2004
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Having to take a mighty shit in someone else's toilet in there house, and hoping they don't smell it before you leave.
"After that cup of coffee, I need to blast off in Danya's shitter!"
by Webster March 31, 2003
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