1. noun. a pain in the ass.
2. noun. an ache generated by sitting too long.

when you're hungover as shit after a spending a night drunk as a skunk

The act in which the inside of your anus feels pumped up and invigorated, normally right before a massive shit.

Something or someone that provides a constant "pain in the ass". You know, that person or thing that's sure to cause unnecessary or unwarranted grief.