Acquired immune deficiency syndrome (AIDS)
Derived from the Cockney rhyming slang phrase "Ace of Spades" = AIDS.
"Did you hear the bad news about Sarah?"
"Yeah, I heard She got dealt The Ace sharing needles in the 'dam (Amsterdam). It's horrible!"

NOTE: -'Sharing needles' refers to the act of sharing a hypodermic needle containing heroin (or a number of other recreational drugs that can be taken this way). Often the second users 'half' will contain traces of blood. This is arguably the easiest way to transmit AIDS or HIV.
by the_frodigy January 28, 2008
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One who is on the broader autistic spectrum, including but not limited to those with autism, Asperger's, hyperlexia, and pervasive developmental disorder not otherwise specified. This definition is sometimes extended to include those with AD(H)D.
The group was open to all ACs, whether professionally or self diagnosed with anything from classic autism to PDD-NOS.
by InvisibleK October 12, 2005
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screwed, not being able o do what you wanted to do
dude yoour so aced
by jason February 08, 2003
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Ass Clown Extrodinaire
That man is an ACE dumbass fool dork akward goofy
by reagleh November 05, 2010
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A starting pitcher with stuff that is so dominant that even when he is not at his best he still has the ability to shut down a team and does shut down teams on a consistent basis.

Not Mark Buehrle.
Mark Buehrle is not an ace.
by Kalapse May 19, 2006
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