"My lord, that man just drank the last bit of Ale..."
"A POX ON HIM"

"A pox on your house"

If you catch the Pox you might die.

Bono is a pox

"That movie was absolutley POX!!

From "a pox on both your houses!" Only its you, you're having bad luck and lots of it. Like, if you keep getting sick, or you're in a fender bender and on the way to the mechanics you're in another you'd say, "Dude, I'm poxed."

I ordered my Rocker BMX from Marfia over a fucking month ago, this is truly pox!