f'd up, inebriated or under the influence of a substance, most likely pills.

The action of getting wrecked by means of alcohol and/or marijuana

A feeling of tiredness, and defeat.

When you loose an item and think it may have been stolen but because of your kind personality you do not want to name a thief as you may find it later

When someone in the Scooby gang has sex

When your brain decides to shut down after a while

When you're so fucked up that you just pass right out, having no knowledge or recollection of the context. Although this use is uncommon, it may also be used to describe being so tired that you fall asleep out of nowhere.