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Line from the movie "The Sandlot," meant to show extreme frustration towards someone's ineptitude or clueless-ness, sometimes both.
"Last night's episode of American Gladiators was wicked?"
"What's American Gladiators?"
"You're killing me, Smalls!"

"Johnson, did you back up those files like I asked"
"Umm,no, sir. I forgot"
"You're killing me, Smalls!"
by Bill so chill August 23, 2008
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2
A quote directly from the film "Sandlot", usually someone will say this out of sexual frustration.
Sophie: *sends a sexy picture to Cameron*
Cameron: "Ugh! You're killing me, Smalls!"
via giphy
by mcfuckkkk April 06, 2017
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