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A more sexually explicit version of, "You couldn't catch a cold", meaning that someone is not good at catching anything.
Wally was so non-athletic, he couldn't catch herpes in a whorehouse.

OR

Being pursued by bad guys: Can't you guys keep up? You couldn't catch herpes in a whorehouse!
by GallopingSausage April 10, 2019
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Apr 21 Word of the Day
I've been jabbed
by Francesco II March 20, 2021
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