Examples:

(1)
Crushes Friend -

"Hey I don't think you and her would work out, so can you stop talking to her?"

You -

"Yeah I'm done"

(2)
Roommate -
"Do you mind paying for the rent again? I promise this is the last time I'll asked"

You -

"Yeah I'm done"

This term can also be said in many different ways, here are a few examples.
(Other ones can put more emphasis how much your done with there shit)
- Yeah fuck this, I'm done
- Well, I'm done
- You know what, I'm done
- Yeah I think I'm done with your shit

phone: why don’t you go to sleep tommy it’s 2 in the morning?
tommy:why don’t you die you dumbazz