Short version of a phrase made popular on the TV show "Scrubs":
"Who's got two thumbs and don't give a shit? Me, Bob Kelso!"

A pick me is a woman that is willing to do anything for male approval. She will embarrass or throw other women under the bus to achieve this goal. The unfortunate thing about a pick me is usually the men they are trying to seek approval from are of poor quality and treat women badly, leaving little real benefit for the pick me.