it's what you say when you don't understand anything the teacher or anyone in school just said.
teacher: the smooth endoplasmic reticulum is ribosome-free and produces proteins and lipids, mitochondrion is the powerhouse of the cell, and the cell membrane controls the movement of materials in the cell.

you: what.
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The answer to life's greatest questions.
Intelligent guy: If vegetarians eat vegetables, what do humanitarians eat? If you take an Oriental person and spin him around several times, does he become disoriented? If love is blind, why is lingerie so popular? When cheese gets its picture taken, does it say 'me'?. Do Lipton Tea employees take coffee breaks?

Me: What?
via giphy
by Name315 February 22, 2018
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When you are so incredibly shocked/surprised all you can say is: what. Not with a question mark, just a monotone, what.
Julia: Hey, I need to tell you something.
Robert: What is it?
Julia: Iโ€™m pregnant.
Robert: What.
by ActuallySensible June 17, 2018
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The ultimate answer to all the questions you want to avoid.
Friend: When are you going to return my socks?
Me: What?
by sharkish potter October 03, 2020
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