Top definition
A statement that is equivalent to what the fuck?. It is very versatile and rolls off the tongue nicely.
You:"Yo man I totally dated that grandma sitting over there,"
Me:"What the Papadopoulos?"

You:"Obama is the president."
Me:"What the Papadopoulos?"
by imnotgivingyouapseudonym November 18, 2009
Happy St. Patties Day!