You use this term when you are about to do something that is really gay, or homosexual. It involves people you are close too and seemingly justifies the act because the people present are supposedly all straight males yet they are committing gay acts, but it is straight since they know it is gay.

A pick me is a woman that is willing to do anything for male approval. She will embarrass or throw other women under the bus to achieve this goal. The unfortunate thing about a pick me is usually the men they are trying to seek approval from are of poor quality and treat women badly, leaving little real benefit for the pick me.