Wayne is a cartoon that came out in the 1996-1997 about a kid with a club foot and his friends in the hood. The theme song is like this "Wayne Head Wayne Head the parties just beguuun". This was a good cartoon

A pick me is a woman that is willing to do anything for male approval. She will embarrass or throw other women under the bus to achieve this goal. The unfortunate thing about a pick me is usually the men they are trying to seek approval from are of poor quality and treat women badly, leaving little real benefit for the pick me.

In New Orleans and south Louisiana somebody that listens to alot of Lil' Wayne, especially from mixtapes, is referred to as a "Wayne Head".

Particular men's hair style featuring gelled up spikes all over the head,
much like the Growing up Gotti Hair-do. Very popular in Wayne, NJ.
Hence the name. Guys wearing this do will also be seen in polo shirts collars up of course, with a sweatband on their forearm and a bottle of vitamin water. Most likely to be seen traveling in packs, typically seen in German luxury cars their parents buy them.