An expression most commonly used when you get confused.

The definition of what the fuck is confusion of why things exist slot of people say what the fuck out of anger or confusion or they may just be referencing that one vine

Say whenever the fuck you want. USually used to imply confusion. Also where, when, how, which the fuck.

yo fool, what are you doing?

1. A more extreme version of what?, expressing anger or frustration.
2. A mantra recited by Counter-Strike players when their kill streak is broken.

A state of having a ton of negative events pile up on you (ie failing a test, crashing a car, having to study for finals etc) and not caring as much as you should. A lot like being fucked and not caring (fucked in a bad way).

Expression used when you see, hear or read something outrageous and completely out of line. Used mostly when the situation is awkward and confusing. And also when its just plain weird.