Totally unrelated to any "opposite" condition of the well-known "born later in the mother's life" disorder, this affliction merely refers to an abnormal obsession with "all things United Parcel Service" --- the person may collect lots of caps and t-shirts with the UPS logo, arbitrarily ship out anything and everything --- even ordinary personal letters, which of course would cost a lot more to ship that way than just a regular US-Mail "Forever" stamp --- by "ol' Brown-'n'-Yellow", always ask to have mail-ordered items shipped to him by UPS even if the US Mail or FedEx would be cheaper, etc.
Caring nephew: My elderly Uncle Ted has developed UPS syndrome in a major way. so I always order his E-Bay items for him myself, so that he won't needlessly overspend on shipping if there is a cheaper way to send the items.
by QuacksO August 29, 2017
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A being of such a massive intellect and high IQ that they are completely unable to function in plebian society.
Oliver is such a god at Smash Bros, I wonder if he has up syndrome.
by Banana Hammie October 29, 2019
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Up Syndrome: You got down syndrome so bad, you probably got up, left, and right syndrome too
by Dickweed69 August 23, 2010
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Up-Syndrome is when you have more than 62 chromosomes (basically being a SPED Class in one person), this usually occurs in when a male and a female have reproductive sex over the age of 50.
This kid with Up-Syndrome is CRAZY!!!
by The Up-Syndrome bot April 11, 2019
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The condition where genitalia is in a perpetually happy state.
"Tom came down with a case of up-syndrome soon after meeting Caroline."

"We always thought Susie was a bit weird, but we didnt know for certain until her secret reared its ugly little head -- she was diagnosed with up-syndrome."

5:00 News Report:
"Rare condition found in man with up-syndrome... Are two penises better than one?"
by PetShelterPimp March 05, 2005
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